What do Reese Witherspoon, Hugh Laurie, Will Arnett, Seth Rogen, Rainn Willson, Stephen Colbert, Kiefer Sutherland and Paul Rudd have in common?  

They all have committed their voices to DreamWorks Animation’s “Monsters vs. Aliens.”

 The plot reinvents the classic ‘50s monster movie as a modern-day action comedy. The story focuses on California girl Susan Murphy (Witherspoon), who is unexpectedly clobbered by a meteor full of outer space gunk and mysteriously grows to 50 feet tall.

According to Variety, Murphy becomes captured and held in a secret government compound. The world learns that the military has been quietly rounding up other monsters over the years, including the brilliant but insect-headed Dr. Cockroach (Laurie) and macho half-ape, half-fish the Missing Link (Arnett). Wilson plays Gallaxhar, Colbert is the president of the U.S., Sutherland portrays General W.R. Monger and Rudd is Susan’s boyfriend, Derek.  

“Monsters vs. Aliens” opens March 27, 2009.