Pandorum is an astronaut’s worse nightmare. Two astronauts awaken in a hyper-sleep chamber aboard an outwardly abandoned spacecraft. The pitch black disorients them, and the only sound is a low rumble and creak from the belly of the spacecraft. They have no memory of anything – who are they, what is their mission?

The only way out of the chamber is a dark and narrow airshaft. Corporal Bower (Ben Foster), the younger of the two, crawls inside, while the other, Lt. Payton (Dennis Quaid), stays behind for guidance on a radio transmitter. As Bower ventures deeper and deeper into the ship, he discovers a terrifying reality. Slowly the spacecraft’s shocking and deadly secrets spin out the truth, and the astronauts come to grips with the fact that survival of mankind centers on their actions.