Variety reports that Denzel Washington is in negotiations to star in the upcoming Tony Scott-directed drama Unstoppable.

Loosely inspired by a true event, the film will have Washington playing an experienced engineer who jumps in a locomotive with a young conductor to chase down a runaway train carrying a cargo of toxic chemicals.

Washington and Scott have worked before four times. They have teamed up on Man on Fire, Deja Vu, Crimson Tide and the upcoming remake The Taking of Pelham 123.

Filming starts this fall.