Harry Potter and the Half-Blood Prince took its wand as a guiding force to movie goers with a magical $21.9 million in its second day of play at the domestic box office for a handsome total of $80.1 million. Ice Age: Dawn of the Dinosaurs came in second while Bruno and Transformers: Revenge of the Fallen took third and fourth. Another new movie, I Love You, Beth Cooper came in eighth.  

1.Harry Potter And The Half Blood Prince 
$80,186,627 — $80,186,627

2.Ice Age: Dawn Of The Dinosaurs
$42,231,885 — $134,304,581

3.Bruno
$41,215,090 — $41,215,090

4.Transformers: Revenge of the Fallen
$35,108,711 — $350,116,636 

5. Public Enemies
$19,464,100 — $71,890,970 

6. The Proposal
$16,536,374 — $119,793,566 

7. The Hangover
$15,055,483 — $227,567,151 

8. I Love You, Beth Cooper
$7,596,376 — $7,596,376 

9. Up
$7,292,253 — $276,411,268 

10. My Sister’s Keeper
$7,057,928 — $38,679,328

(Source)